Endocrine Abstracts

We previously reported the impact of low-carbohydrate/high-fat (LC–HF) diets on different endocrine systems in rats. To unravel metabolic pathways involved, we now studied if pair-feeding isoenergetic amounts of three different diets – all composed of macronutrient from the same sources but at different relative abundance, – leads to specific changes of the plasma metabolic profile.Methods: Plasma was collected from male Wistar rats (n<...

In rats, we have previously demonstrated that consumption of low-carbohydrate/high-fat diets (LC–HFD) led to significant reductions in circulating IGF1. We further observed that rats fed an extreme, ketogenic, but comparably low protein LC–HFD (LC–HF-2) showed loss of bodyweight, which was mainly due to loss of lean body mass (LBM). Consumption of a moderate protein LC–HF diet (LC–HF-1) did not affect LBM acquisition compared to controls. We now invest...